Miconazole in Systemic Candidosis

Persistence of miconazole in vaginal secretions after single applications. Implications for the treatment of vaginal candidosis.

In vaginal secretions from 16 healthy women aged between 20 and 27 years miconazole persisted in biodetectable concentrations for at least 48 hours after insertion of a single miconazole vaginal pessary. This finding casts doubt on cure rates in vaginal candidosis determined soon after the end of treatment and suggests that current treatment courses with imidazole antifungal agents may be longe...

Neonatal systemic candidiasis treated with miconazole.

Recurrent vaginal candidosis: prospective study of effectiveness of maintenance miconazole treatment.

In a prospective study, 100 women with recurrent vaginal candidosis were treated with miconazole, using two 100 mg vaginal pessaries a day for one week, then one pessary twice a week for three months followed by one pessary a week for a further three months. Fifty four women elected to continue using one pessary a week for longer than six months. Symptomatic vaginal candidosis did not occur in ...

Systemic candidosis in silica-treated athymic and euthymic mice.

Intravenous silica injections were used to assess the role of macrophages in the resistance of BALB/c nude and euthymic mice to systemic candidosis. CFU of Candida albicans in the kidneys, livers, and spleens of saline- or silica-treated mice were enumerated at various times after inoculation with 10(4) viable yeast cells. The number of C. albicans organisms recovered from the kidneys of silica...

Neonatal systemic candidiasis: a failure to respond to intravenous miconazole in two neonates.

a superimposed nutritional deficiency which further impairs their resistance, especially to diarrhoeal disease. This suggests that one important cause of postneonatal mortality in Latin America is low birthweight, possibly as a result of poor maternal health and nutritional status. In other parts of the world-for example in Africa and the Indian subcontinent-the prevalence of low birthweight is...